- Cossart, P., P. Boquet, S. Normark, and R. Rappuoli. Cellular Microbiology Emerging Science, January 19, 1996.
How pathogenic bacteria interfere with host-cell signaling pathways and other cell functions, and the use of these pathogens as tools for basic research.
- Downward, J. Metabolism Meets Death Nature, August 21, 2003
The signaling pathway associated with glucose metabolism appears to share a component with the pathway associated with programmed cell death (apoptosis), suggesting a point of intersection.
- Etienne-Manneville, S., and A. Hall. Rho GTPases in Cell Biology Nature, December 12, 2002.
This review article focuses on the Rho GTPases, proteins that act as molecular switches controlling a wide variety of signal-transduction pathways in all eukaryotic cells.
- Featherstone, C. The Many Faces of WAS Protein Science, January 3, 1997.
More about the protein that is missing in people with Wiskott-Aldrich syndrome.
- Harbron, P. Conversation in a Cell Discover, February 1996.
Stuart Schreiber's research on cell signaling, which began with an investigation of the sex attractant of cockroaches.
- Ingolia, N. T., and A. W. Murray. History Matters Science (Perspective), August 9, 2002.
This article discusses a research article in the same issue about the mitogen-activated protein (MAP) kinases 1 and 2, important regulators of many cellular processes: Bhalla, U. S., P. T. Ram, and R. Iyengar, "MAP Kinase Phosphatase as a Locus of Flexibility in a Mitogen-Activated Protein Kinase Signaling Network."
- Noselli, S., and N. Perrimon. Are There Close Encounters Between Signaling Pathways? Science, October 6, 2000.
How do different signaling pathways in a cell "talk" to each other?
- Park, J. M., F. R. Greten, Z.-W. Li, and M. Karin. Macrophage Apoptosis by Anthrax Lethal Factor Through p38 MAP Kinase Inhibition Science, September 20, 2002.
The bacterium that causes anthrax apparently evades the immune system by interfering in an important cell-signaling pathway in a way that induces certain activated immune cells to commit suicide.
- Pawson, T., and P. Nash. Assembly of Cell Regulatory Systems Through Protein Interaction Domains Science, April 18, 2003.
This article focuses on regions of proteins, or domains, capable of interacting with other proteins. Cataloging these protein interaction domains provides a database with which to compare newly obtained protein sequences and thus attempt to predict their functions.
- Pouysségur, J. An Arresting Start for MAPK Science, November 24, 2000.
Protein kinases, especially the ones called MAPKs, are important components of many signal- transduction pathways. How does a cell prevent inappropriate cross-talk between these pathways?
- Strauss, E. A Symphony of Bacterial Voices Science, May 21, 1999.]**
Some detailed information about how bacteria communicate with members of both their own species and other species.
- Wrana, J. L. On the Wings of Inhibition Nature, December 12, 2002.]**
An interplay between growth factors and specific inhibitors often regulates cell-signaling processes. This article describes research on the structure of an important growth factor (bone morphogenetic protein 7, or BMP-7) and an inhibitor called Noggin.
